Endocrine Abstracts

Decreased GH secretion and increased GH clearance contribute to low GH levels found in obesity; in spite of which IGF-1 levels are reported as normal. To explain the discordancy between GH and IGF-1 status in obese subjects, an increase in peripheral (hepatic) sensitivity to GH activity has been hypothesized. Previously peripheral responsiveness to GH in obesity has been investigated and reported to be increased, however the use of weight-based GH doses made interpretation dif...